RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
Bmpr2;Wwp1; Satb1; Yod1
Pathway
NA
PubMed ID
Title
MiR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling
Year
2012
Function
"MiR-21 expression is increased in distal small arteries in the lungs of hypoxia-exposed mice. Putative miR-21 targets, including bone morphogenetic protein receptor (BMPR2), WWP1, SATB1, and YOD1, were downregulated in the lungs of hypoxia-exposed mice and in human pulmonary artery smooth muscle cells (PASMCs) overexpressing miR-21.Sequestration of miR-21, either before or after hypoxia exposure, diminished chronic hypoxia-induced PH and attenuated hypoxia-induced pulmonary vascular remodeling, likely through relieving the suppressed expression of miR-21 targets in the lungs of hypoxia-exposed mice."